Everton make two changes to the side that beat Nottingham Forest 2-0 here on Sunday.
Ashley Young, who was sent off in the reverse fixture, is replaced at right-back by Ben Godfrey, while James Garner comes in for Andre Gomes.
The Toffees are boosted by the news that Dominic Calvert-Lewin is fit to start up front after suffering a knock.
Striker Beto is out and following concussion protocols after being knocked unconscious against Forest.
Amadou Onana remains on the bench.
Everton XI: Pickford, Godfrey, Tarkowski, Branthwaite, Mykolenko, Gueye, Harrison, Doucoure, Garner, McNeil, Calvert-Lewin.
Liverpool boss Jurgen Klopp has shuffled the pack for the derby, making six changes to the side that beat Fulham on Sunday.
Big hitters Mohamed Salah, Alexis Mac Allister and Darwin Nunez return to the starting line-up, as do Dominik Szoboszlai, Curtis Jones and Ibrahima Konate.
Diogo Jota faces a spell on the sidelines, while Cody Gakpo, Ryan Gravenberch, Wataru Endo, Harvey Elliott and Jarrell Quansah all drop out.
Liverpool XI: Alisson, Alexander-Arnold, Konate, Van Dijk, Robertson, Szoboszlai, Mac Allister, Jones, Diaz, Salah, Nunez.